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Darunavir oral suspension

What is this medicine?

DARUNAVIR (da ROON a veer) is an antiretroviral medicine. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. This medicine can lower, but not fully prevent, the risk of spreading HIV to others.

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Shake well before using. Take this medicine with food. Use a specially marked spoon or dropper to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 3 years for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • increased hunger or thirst

  • muscle or joint pain

  • rash, fever, and swollen lymph nodes

  • redness or swelling of the eyes

  • redness, blistering, peeling or loosening of the skin, including inside the mouth

  • signs of infection like fever or chills; cough; sore throat; pain or trouble passing urine

  • signs of liver injury like dark yellow or brown urine; generally ill feeling of flu-like symptoms; light-colored stools; loss of appetite; nausea or vomiting; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin

  • signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision.

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • headache

  • stomach pain

  • upset stomach

  • weight gain around waist, back, or thinning of face, arms, legs

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • alfuzosin

  • certain medicines for blood pressure, heart disease, irregular heart beat such as dronedarone, ivabradine, ranolazine

  • cisapride

  • colchicine (if you have liver or kidney problems)

  • elbasvir; grazoprevir

  • lurasidone

  • medicines for cholesterol such as lomitapide, lovastatin, simvastatin

  • medicines for headaches such as dihydroergotamine, ergonovine, ergotamine, methylergonovine

  • midazolam

  • naloxegol

  • pimozide

  • red yeast rice

  • rifampin

  • sildenafil (for the treatment of pulmonary arterial hypertension)

  • St. John's Wort

  • triazolam

This medicine may also interact with the following medications:

  • artemether; lumefantrine

  • bosentan

  • certain antibiotics such as clarithromycin, rifabutin, rifapentine

  • certain other antiviral medicines for HIV such as didanosine, indinavir, maraviroc, saquinavir, or lopinavir; ritonavir

  • certain medicines for anxiety or sleep such as buspirone, diazepam, estazolam, zolpidem

  • certain medicines for blood pressure and heart disease such as amlodipine, carvedilol, diltiazem, felodipine, metoprolol, nicardipine, nifedipine, timolol, verapamil

  • certain medicines for cancer such as dasatinib, nilotinib, vinblastine, vincristine

  • certain medicines for depression such as amitriptyline, desipramine, imipramine, nortriptyline, paroxetine, sertraline, and trazodone

  • certain medicines for erectile dysfunction such as avanafil, sildenafil, tadalafil, vardenafil

  • certain medicines for fungal infection such as itraconazole, ketoconazole, posaconazole, voriconazole

  • certain medicines for hepatitis infection such as boceprevir, simeprevir

  • certain medicines for psychotic disturbances such as quetiapine, risperidone, thioridazine

  • certain medicines for seizures such as carbamazepine, phenobarbital, phenytoin

  • certain medicines that treat or prevent blood clots such as apixaban, rivaroxaban, warfarin

  • clopidogrel

  • female hormones such as estrogens and progestins and birth control pills

  • medicines for cholesterol such as atorvastatin, pravastatin, rosuvastatin

  • medicines for irregular heart beat such as amiodarone, bepridil, digoxin, disopyramide, flecainide, lidocaine, mexiletine, propafenone, quinidine

  • medicines that lower your chance of fighting infection such as cyclosporine, everolimus, sirolimus, tacrolimus

  • narcotic medicines for pain such as buprenorphine, buprenorphine; naloxone, methadone

  • omeprazole

  • salmeterol

  • steroid medicines such as betamethasone, budesonide, ciclesonide, dexamethasone, fluticasone, methylprednisolone, mometasone, prednisolone, triamcinolone

  • ticagrelor

What if I miss a dose?

If you miss a dose, take it as soon as you can. If you usually take your medicine once a day and your next dose is to be taken in less than 12 hours, then do not take the missed dose. If you usually take your medicine twice a day and your next dose is to be taken in less than 6 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • diabetes

  • hemophilia

  • liver disease

  • an unusual or allergic reaction to darunavir, sulfa medicines, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or healthcare provider for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.

This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your healthcare provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control. Women who can still have children must use a reliable form of barrier contraception, like a condom or diaphragm.

This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.

NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2021 Elsevier
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